Which statement best differentiates Paget's disease from Hodgkin's disease based on ALP and LDH?

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Multiple Choice

Which statement best differentiates Paget's disease from Hodgkin's disease based on ALP and LDH?

ALP rises with increased bone turnover, while LDH rises with rapid cell turnover and tissue breakdown. Paget's disease is a bone remodeling disorder, so ALP is elevated; LDH tends to remain normal unless there’s a complication. Hodgkin's lymphoma typically shows elevated LDH due to tumor activity, and ALP is not characteristically raised unless there’s bone involvement. Therefore, the statement that Paget's disease shows an increased ALP without an increase in LDH best differentiates the two. The other patterns don’t match the usual lab behavior of these diseases.

ALP rises with increased bone turnover, while LDH rises with rapid cell turnover and tissue breakdown. Paget's disease is a bone remodeling disorder, so ALP is elevated; LDH tends to remain normal unless there’s a complication. Hodgkin's lymphoma typically shows elevated LDH due to tumor activity, and ALP is not characteristically raised unless there’s bone involvement. Therefore, the statement that Paget's disease shows an increased ALP without an increase in LDH best differentiates the two. The other patterns don’t match the usual lab behavior of these diseases.

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