Which statement best describes a hallmark metabolic abnormality in Fanconi's syndrome?

Prepare for the CAMLPR Chemistry Test. Enhance your understanding with interactive quizzes, flashcards, and detailed explanations. Boost your confidence and readiness for exam success!

Multiple Choice

Which statement best describes a hallmark metabolic abnormality in Fanconi's syndrome?

Fanconi syndrome is a proximal renal tubule dysfunction where reabsorption of many filtered substances (glucose, phosphate, amino acids, bicarbonate) is impaired. Because the tubule can't reabsorb glucose, it appears in the urine even though blood glucose is normal—this is glycosuria with eu glycemia. Protein in the urine can also be present due to loss of low-molecular-weight proteins, and bicarbonate loss contributes to a metabolic acidosis. So the hallmark metabolic abnormality described by the statement is glucosuria with proteinuria and normal blood glucose. Hyperglycemia would point to diabetes, not a tubular defect; hypoglycemia is not typical; Bence Jones proteins signal a different condition like a plasma cell disorder.

Fanconi syndrome is a proximal renal tubule dysfunction where reabsorption of many filtered substances (glucose, phosphate, amino acids, bicarbonate) is impaired. Because the tubule can't reabsorb glucose, it appears in the urine even though blood glucose is normal—this is glycosuria with eu glycemia. Protein in the urine can also be present due to loss of low-molecular-weight proteins, and bicarbonate loss contributes to a metabolic acidosis. So the hallmark metabolic abnormality described by the statement is glucosuria with proteinuria and normal blood glucose. Hyperglycemia would point to diabetes, not a tubular defect; hypoglycemia is not typical; Bence Jones proteins signal a different condition like a plasma cell disorder.

More practice questions