Which serum protein electrophoresis pattern is typical of nephrotic syndrome?

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Multiple Choice

Which serum protein electrophoresis pattern is typical of nephrotic syndrome?

Nephrotic syndrome causes heavy loss of protein in the urine, especially albumin, leading to low blood albumin (hypoalbuminemia). In response, the liver increases production of other serum proteins, so the albumin band falls while the alpha-2 and beta globulin bands rise on serum protein electrophoresis. This shift—low albumin with elevated alpha-2 and beta globulins—is the typical pattern seen in nephrotic syndrome, making the described pattern the best fit.

Nephrotic syndrome causes heavy loss of protein in the urine, especially albumin, leading to low blood albumin (hypoalbuminemia). In response, the liver increases production of other serum proteins, so the albumin band falls while the alpha-2 and beta globulin bands rise on serum protein electrophoresis. This shift—low albumin with elevated alpha-2 and beta globulins—is the typical pattern seen in nephrotic syndrome, making the described pattern the best fit.

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