Which of the following sets of analyte changes would be observed in Hodgkin's disease?

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Multiple Choice

Which of the following sets of analyte changes would be observed in Hodgkin's disease?

In Hodgkin's disease, you often see signs of tumor activity and organ involvement reflected in the labs. LDH rises because of increased cell turnover and tumor burden—the malignant cells release LDH as they proliferate and die. Alkaline phosphatase goes up when there’s involvement of the liver or bone, which can occur with Hodgkin’s disease either due to hepatic infiltration or secondary effects on the biliary system or skeleton. Seeing both LDH and ALP elevated fits a pattern of more extensive disease with organ involvement, whereas calcium elevation is not a typical or consistent finding in Hodgkin's. So the combination of increased ALP and LDH aligns with what’s observed in this condition.

In Hodgkin's disease, you often see signs of tumor activity and organ involvement reflected in the labs. LDH rises because of increased cell turnover and tumor burden—the malignant cells release LDH as they proliferate and die. Alkaline phosphatase goes up when there’s involvement of the liver or bone, which can occur with Hodgkin’s disease either due to hepatic infiltration or secondary effects on the biliary system or skeleton. Seeing both LDH and ALP elevated fits a pattern of more extensive disease with organ involvement, whereas calcium elevation is not a typical or consistent finding in Hodgkin's. So the combination of increased ALP and LDH aligns with what’s observed in this condition.

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