Which of the following lists reflects the plasma/serum changes associated with Paget's disease?

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Multiple Choice

Which of the following lists reflects the plasma/serum changes associated with Paget's disease?

Paget's disease causes accelerated bone turnover driven by highly active osteoblasts, so alkaline phosphatase, a marker of bone formation, rises in the blood. Calcium levels are typically normal because calcium homeostasis is tightly regulated, and LDH is not a reliable or consistent marker in this condition. Therefore, the serum change that best fits Paget's is an increase in ALP alone.

Paget's disease causes accelerated bone turnover driven by highly active osteoblasts, so alkaline phosphatase, a marker of bone formation, rises in the blood. Calcium levels are typically normal because calcium homeostasis is tightly regulated, and LDH is not a reliable or consistent marker in this condition. Therefore, the serum change that best fits Paget's is an increase in ALP alone.

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