Which disorder is associated with Alpha-1 Antitrypsin Deficiency leading to emphysema?

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Multiple Choice

Which disorder is associated with Alpha-1 Antitrypsin Deficiency leading to emphysema?

Alpha-1 antitrypsin deficiency directly predisposes to emphysema because it removes the protection against neutrophil elastase in the lungs. Without enough inhibitor, elastase digs through elastic tissue in the alveolar walls, leading to early-onset panacinar emphysema even in people who don’t smoke. The same genetic defect also affects the liver, where the misfolded protein can accumulate and cause cirrhosis in some individuals. So, the disorder that ties to emphysema in this context is the deficiency itself, since the lack of inhibition in the lungs is the key mechanism driving the emphysema.

Alpha-1 antitrypsin deficiency directly predisposes to emphysema because it removes the protection against neutrophil elastase in the lungs. Without enough inhibitor, elastase digs through elastic tissue in the alveolar walls, leading to early-onset panacinar emphysema even in people who don’t smoke. The same genetic defect also affects the liver, where the misfolded protein can accumulate and cause cirrhosis in some individuals. So, the disorder that ties to emphysema in this context is the deficiency itself, since the lack of inhibition in the lungs is the key mechanism driving the emphysema.

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