Which analytes would be ordered for Duchenne muscular dystrophy and what would the expected results be?

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Multiple Choice

Which analytes would be ordered for Duchenne muscular dystrophy and what would the expected results be?

Explanation:
Muscle breakdown in Duchenne muscular dystrophy releases intracellular enzymes into the bloodstream, so markers of muscle injury rise. Creatine kinase is highly sensitive to muscle damage and LDH is released with tissue breakdown, so both increase. Alanine aminotransferase is also released from damaged muscle, so its level can be elevated as well, even though it’s classically a liver enzyme. At the same time, decreased muscle mass means less creatinine production, so serum creatinine tends to be lower than normal. This combination—ALT up, CK up, creatinine down, LDH up—fits the expected laboratory pattern for Duchenne muscular dystrophy.

Muscle breakdown in Duchenne muscular dystrophy releases intracellular enzymes into the bloodstream, so markers of muscle injury rise. Creatine kinase is highly sensitive to muscle damage and LDH is released with tissue breakdown, so both increase. Alanine aminotransferase is also released from damaged muscle, so its level can be elevated as well, even though it’s classically a liver enzyme. At the same time, decreased muscle mass means less creatinine production, so serum creatinine tends to be lower than normal. This combination—ALT up, CK up, creatinine down, LDH up—fits the expected laboratory pattern for Duchenne muscular dystrophy.

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