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Multiple Choice

LDH 630 U/L; CK 1500 U/L; CREA 130 umol/L; Urinalysis: BLOOD 1+. What is the suspected diagnosis?

High CK with elevated LDH signals active muscle breakdown. The urinalysis showing blood on the dipstick with few or no red blood cells points to myoglobin in the urine, i.e., myoglobinuria from rhabdomyolysis rather than true hematuria. Rhabdomyolysis is a known feature in certain muscular disorders, especially mitochondrial myopathies, where exertion or stress can trigger muscle breakdown and release myoglobin and enzymes into blood. The creatinine is only mildly elevated, so there isn’t clear evidence of acute kidney injury yet, which would typically accompany more severe renal impairment. Duchenne’s or congenital myopathies don’t usually present with myoglobinuria as a defining feature, though they can raise CK; the combination here most strongly aligns with mitochondrial myopathy presenting with rhabdomyolysis and myoglobinuria.

High CK with elevated LDH signals active muscle breakdown. The urinalysis showing blood on the dipstick with few or no red blood cells points to myoglobin in the urine, i.e., myoglobinuria from rhabdomyolysis rather than true hematuria. Rhabdomyolysis is a known feature in certain muscular disorders, especially mitochondrial myopathies, where exertion or stress can trigger muscle breakdown and release myoglobin and enzymes into blood. The creatinine is only mildly elevated, so there isn’t clear evidence of acute kidney injury yet, which would typically accompany more severe renal impairment. Duchenne’s or congenital myopathies don’t usually present with myoglobinuria as a defining feature, though they can raise CK; the combination here most strongly aligns with mitochondrial myopathy presenting with rhabdomyolysis and myoglobinuria.