In Waldenström’s macroglobulinemia, which analytes would be ordered and what would be the expected results?

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Multiple Choice

In Waldenström’s macroglobulinemia, which analytes would be ordered and what would be the expected results?

Waldenström’s macroglobulinemia is a lymphoplasmacytic lymphoma that produces a monoclonal IgM antibody. Because the malignant clone makes IgM, serum IgM levels rise markedly. The IgM paraprotein also increases the total serum protein, contributing to hyperviscosity. Therefore, when evaluating suspected Waldenström’s, the key lab feature is an elevated IgM level, with total protein often elevated as well. The option reflecting an increased IgM best matches the disease’s characteristic finding, which is why it is the strongest choice.

Waldenström’s macroglobulinemia is a lymphoplasmacytic lymphoma that produces a monoclonal IgM antibody. Because the malignant clone makes IgM, serum IgM levels rise markedly. The IgM paraprotein also increases the total serum protein, contributing to hyperviscosity. Therefore, when evaluating suspected Waldenström’s, the key lab feature is an elevated IgM level, with total protein often elevated as well. The option reflecting an increased IgM best matches the disease’s characteristic finding, which is why it is the strongest choice.

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