In nephrotic syndrome, which pattern is observed on electrophoresis?

Prepare for the CAMLPR Chemistry Test. Enhance your understanding with interactive quizzes, flashcards, and detailed explanations. Boost your confidence and readiness for exam success!

Multiple Choice

In nephrotic syndrome, which pattern is observed on electrophoresis?

Heavy protein loss in nephrotic syndrome lowers circulating albumin. To compensate, the liver increases production of other plasma proteins, especially acute-phase and transport proteins that show up in the alpha-2 and beta regions on serum protein electrophoresis. Meanwhile, gamma globulins are often reduced because immunoglobulins are lost in the urine. So the pattern that fits is a decreased albumin with relative increases in alpha-2 and beta globulins.

Heavy protein loss in nephrotic syndrome lowers circulating albumin. To compensate, the liver increases production of other plasma proteins, especially acute-phase and transport proteins that show up in the alpha-2 and beta regions on serum protein electrophoresis. Meanwhile, gamma globulins are often reduced because immunoglobulins are lost in the urine. So the pattern that fits is a decreased albumin with relative increases in alpha-2 and beta globulins.

More practice questions