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Multiple Choice

In MS suspicion, which analyte increases?

In suspected multiple sclerosis, there is increased production of immunoglobulins within the central nervous system, so CSF markers that reflect intrathecal Ig synthesis rise. The option that indicates an increase in CSF POR aligns with this rise in CSF immunoglobulin-related activity, making it the best choice. The other options involve CK, a muscle enzyme, which is not a marker of CNS inflammatory activity, or suggest decreases that don’t fit the typical MS CSF pattern.

In suspected multiple sclerosis, there is increased production of immunoglobulins within the central nervous system, so CSF markers that reflect intrathecal Ig synthesis rise. The option that indicates an increase in CSF POR aligns with this rise in CSF immunoglobulin-related activity, making it the best choice. The other options involve CK, a muscle enzyme, which is not a marker of CNS inflammatory activity, or suggest decreases that don’t fit the typical MS CSF pattern.