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Multiple Choice

In diabetes mellitus, which urine analyte would be inc?

Diabetes can damage the kidneys, making the glomerular barrier more permeable to proteins. Albumin, a relatively small protein, starts leaking into the urine early in this process. This early leakage is called microalbuminuria and is a sensitive indicator of diabetic nephropathy, appearing before larger amounts of protein are detectable by standard tests. So microalbumin in urine would be increased. Urine glucose can appear when blood glucose exceeds the kidney’s reabsorption capacity, but it’s not as reliable an early marker of diabetic kidney involvement. Urine protein as a general measurement is less specific for early diabetic damage, since larger amounts of protein may appear later or due to other kidney issues. Urine creatinine by itself isn’t increased due to diabetes; it’s used in combination with albumin to assess the rate of albumin excretion (albumin-to-creatinine ratio).

Diabetes can damage the kidneys, making the glomerular barrier more permeable to proteins. Albumin, a relatively small protein, starts leaking into the urine early in this process. This early leakage is called microalbuminuria and is a sensitive indicator of diabetic nephropathy, appearing before larger amounts of protein are detectable by standard tests. So microalbumin in urine would be increased.

Urine glucose can appear when blood glucose exceeds the kidney’s reabsorption capacity, but it’s not as reliable an early marker of diabetic kidney involvement. Urine protein as a general measurement is less specific for early diabetic damage, since larger amounts of protein may appear later or due to other kidney issues. Urine creatinine by itself isn’t increased due to diabetes; it’s used in combination with albumin to assess the rate of albumin excretion (albumin-to-creatinine ratio).