Glucose measurement may be affected by icodextrin. What kind of error can icodextrin cause in Trinder's glucose oxidase readings?

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Multiple Choice

Glucose measurement may be affected by icodextrin. What kind of error can icodextrin cause in Trinder's glucose oxidase readings?

When using the Trinder colorimetric method with glucose oxidase, the measured signal depends on hydrogen peroxide produced from glucose. Icodextrin is a glucose polymer that, in the body, is broken down into glucose and glucose-like oligosaccharides. These substances can contribute additional oxidizable material or interfere with the color reaction, producing more color development than glucose alone. The result is a falsely elevated glucose reading with this method. Hexokinase assays are less affected by icodextrin, so the interference is specific to glucose oxidase-based (Trinder) readings.

When using the Trinder colorimetric method with glucose oxidase, the measured signal depends on hydrogen peroxide produced from glucose. Icodextrin is a glucose polymer that, in the body, is broken down into glucose and glucose-like oligosaccharides. These substances can contribute additional oxidizable material or interfere with the color reaction, producing more color development than glucose alone. The result is a falsely elevated glucose reading with this method. Hexokinase assays are less affected by icodextrin, so the interference is specific to glucose oxidase-based (Trinder) readings.

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