A patient has GLU 8.9 mmol/L and Sweat Osmolality 70 mmol/L. What is the likely diagnosis?

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Multiple Choice

A patient has GLU 8.9 mmol/L and Sweat Osmolality 70 mmol/L. What is the likely diagnosis?

Concentrated, salty sweat points to cystic fibrosis. The CFTR defect in sweat glands impairs reabsorption of sodium and chloride, so the final sweat becomes hyperosmolar. A sweat osmolality of 70 mmol/L is elevated and consistent with this pattern, whereas diabetes would be diagnosed by blood glucose rather than sweat osmolality, and Addison’s disease or hyperlipidemia don’t produce this salty, high-osmolality sweat. So, the ski pattern of high sweat osmolality makes cystic fibrosis the most likely diagnosis.

Concentrated, salty sweat points to cystic fibrosis. The CFTR defect in sweat glands impairs reabsorption of sodium and chloride, so the final sweat becomes hyperosmolar. A sweat osmolality of 70 mmol/L is elevated and consistent with this pattern, whereas diabetes would be diagnosed by blood glucose rather than sweat osmolality, and Addison’s disease or hyperlipidemia don’t produce this salty, high-osmolality sweat. So, the ski pattern of high sweat osmolality makes cystic fibrosis the most likely diagnosis.

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